Studies of syphilitic antibodies. IV. Evidence of reactant partner common for C-reactive protein and certain anti-lipoidal antibodies.
نویسنده
چکیده
Certain surface active substances produce a non-syphilitic flocculation reaction if cardiolipin is replaced by them in the VDRL test system (Tuomioja 2nd Kajanne, 1956). The test was called the APC test because these surface active substances were products of the Atlas Powder Company (Wilmington, Delaware). The most active was Span 60, stated by the manufacturer to be mainly sorbitan monostearate. This APC test gave results parallel to the C-reactive protein (CRP) antiserum precipitation test (Tuomioja, Kajanne, Wager, and Hallstrom, 1956). The readings were as clearcut as those in the VDRL test for syphilis. The exact relationship of CRP with the substances producing flocculation in the APC test remained in doubt and the present work was initiated to clarify this question. The role of CRP in the flocculation reaction was established, but it was proved that an antibody also combines with the APC antigen, and some of its properties are described.
منابع مشابه
Studies of syphilitic antibodies. II. Substances responsible for biological false positive sero-reactions.
It has been generally assumed that the substances responsible for biological false positive (BFP) seroreactions for syphilis are antibodies of the same kind as the syphilitic anti-lipoidal antibodies. However, the available evidence for this view is meagre and mainly circumstantial. It has been observed that in the VDRL test substitution of the cardiolipin in the antigen by certain surface-acti...
متن کاملStudies of syphilitic antibodies. I. Anti-lipoidal antibodies in various stages of syphilis.
There is good evidence to indicate that the syphilitic anti-lipoidal "reagins" are true antibodies. They appear in demonstrable amounts in the serum 4 to 6 weeks from the date of infection and at about the same time as the most sensitive treponemal test, the FTA-ABS test, becomes positive (Deacon, Lucas, and Price, 1966; Lassus, Mustakallio, Aho, and Putkonen, 1967). Uniformly high titres are r...
متن کاملStudies of syphilitic antibodies. 3. Anamnestic reactions and 19S predominance of the anti-lipoidal antibodies in aged persons.
Syphilitic anti-lipoidal antibodies as detected by the standard tests for syphilis (STS) are usually recovered in both yM (19S) and yG (7S) globulin fractions (Davis, Moore, Kabat, and Harris, 1945; Laurell and Malmqvist, 1961; Aho, 1967), whereas substances responsible for biologic false positive (BFP) reactions are found in most instances solely in the yM globulin fraction (Aho, 1968). Syphil...
متن کاملFrequency and Accuracy of Anti-Citrullinated Protein Antibodies, Prognostic Evaluation in Overall Developing to Erosive Disease in Patients with Psoriatic Seronegative Osteoarthropathy
Anti-cyclic peptide antibodies (CCP/ACPA) are directed towards synthetic citrullinated peptides and are specific markers in diagnosis of Rheumatoid arthritis. This study aimed to compare the values and acuracy of the test in anticyclic citrullinated peptides (Anti-CCP /ACPA) antibodies, rheumatoid factor (RF), C-reactive protein (CRP) and disease activity index (PASI) in early diagnosis of untr...
متن کاملDevelopment and ELISA-based detection of anti-M2e IgY antibodies using an encoding plasmid for M2e-Hsp70 C-terminal gene
Background: The use of IgYs in a variety of methods in different areas of research, diagnostics, medical application and biotechnology should be considered widely. Objectives: Development of antibodies against extra cellular domain of influenza M2 (M2e) protein in egg yolk of laying hens. Methods: A Fusion construct harboring C-terminal of bovine heat shock protein 70 (Hsp70) and influenza M2e ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The British journal of venereal diseases
دوره 45 1 شماره
صفحات -
تاریخ انتشار 1969